Ergothioneine is a naturally occurring amino acid derivative with antioxidant properties. It is mainly in certain fungi and actinobacteria. Due to its ability to scavenge free radicals and protect cells from oxidative stress, it has wide use in cosmetics.
Overview
Product name : Ergothioneine
INCI name : L-(+)-Ergothioneine (EGT)
CAS No. : 497-30-3
EINECS NO. : 207-843-5
Molecular Formula : C9H15N3O2S
Category : Antioxidant for skin
Chemical structure : 
Ergothioneine Specification
| Item | Specification |
| Appearance | White crystal |
| Smell | Characteristic odor |
| Purity (normalization method) | ≥99.96% |
| Melting Point | 275-277℃ |
| Optical rotation | [a]D≥(+)122°(c=1,H2O) |
| Loss on Drying | ≤0.50% |
| Elemental analysis | C : 47.14 + 0.3% H : 6.59 + 0.3% N : 18.33 + 0.3% |
| Melting Range | 64.50~68.50℃ |
| As | ≤0.10ppm |
| Pb | ≤0.10ppm |
| Hg | ≤0.10ppm |
| Cd | ≤0.10ppm |
| Total Heavy Metals | ≤10.00ppm |
| Total Residual Solvents | ≤1000.00ppm |
| E. coli | Negative / 25g |
| Staphyloccocus aureus | Negative / 25g |
| P aeruginosa | ≤100 CFU / g |
| Total Yeast and Mold Counts | ≤100 CFU / g |
| Total Viable Aerobic Count | ≤100 CFU / g |
Ergothioneine Features
Super strong natural antioxidant
Antioxidant Source – Mitochondria (Intelligent, Targeted)
Broad spectrum, safe, stable, and long-lasting
Synergistic activity
Ergothioneine Main Efficacy
- Scavenge free radicaal
- Support mitochondrial healt
- Supports Cardiovascular Hea
- An-aging
- Boost immunity
- Anti- inflammatory
- Skin care
- Cell protectant
- Support longevity
- Improve cognition
- Protect organs from Coronavir
Ergothioneine Application
Skin Care
Ergothioneine has benefits for skin health. It has wide use in skincare products to help protect the skin from oxidative stress, UV radiation, and environmental pollutants.
Antioxidant and Anti-Inflammatory
Ergothioneine is famous for its antioxidant and anti-inflammatory effects. It can help protect cells from damage caused by free radicals, which are implicated in various diseases, including cardiovascular diseases, neurodegenerative disorders, and aging.
Dietary Supplements
Ergothioneine is available as a dietary supplement. Some people choose to take it as a supplement to support overall health and well-being, especially if they have concerns about oxidative stress.
Neuroprotection
Due to its antioxidant properties, EGT has potential neuroprotective effects. It plays a role in protecting nerve cells from damage and supporting cognitive function.
Anti-Aging
The antioxidant properties of EGT make it a candidate for anti-aging formulations. It helps counteract the effects of oxidative stress on cells and tissues, potentially slowing down the aging process.
Food Preservation
EGT has potential use as a food preservative. Its antioxidant properties helps extend the shelf life of certain food products by protecting them from oxidation.
Medical
Research is ongoing to explore the potential therapeutic applications of EGT in various medical conditions, including inflammatory disorders and diseases associated with oxidative stress.
Experimental Packing
1kg, 10kg, 25kg/bag or drum
Storage
Keep in cool and dry place.
Ergothioneine Clear UVA induction experiment
Experimental program I :
Pretreat HSF cells with EGT (0.125-0.5 μM) cells for 24 hours, and then irradiated with 3J/cm2 UVA cells, using DCF to display intracellular ROS levels, and Observe with a fluorescence microscope (200x magnification).
Experimental Conclusion I :
Pretreat HSF cells with 0.13ppm EGT solution,the ROS clearance rate reaches 90%.
Ergothioneine Clear UVB induction experiment
Experimental program II :
Keratinocytes (HaCaT) were pretreated with different concentrations of EGT culture solution for 2 hours, the culture medium was replaced, UVB (20mJ/cm2) was exposed, and the cells were incubated with fibroblasts at 37°C for 48 hours and then the cell ROS levels were tested.
Experimental Conclusion II :
Pre treatment of HaCaT cells with 0.2% EGT solution resulted in a ROS clearance rate of 75%.
