Glyoxylic acid 50% is used for pharmaceuticals.
Threo-2-hydroxy-3-acetylamino-4-oxo-4-phenylbutanoic acid, CAS NO.: 87081-54-7, also call Threo-4-oxo-(3-Acetyl)-(2RS)-AHPA.
It is white powder, and the measured purity of the product is over 98%. Threo-2-hydroxy-3-acetylamino-4-oxo-4-phenylbutanoic acid can be used to synthesize ubenmex.
Below is one new producing method with material Glyoxylic acid 50% solution or Glyoxylic acid monohydrate.
1. Acetophenone + 1,3-Dibromo-5,5-dimethylhydantoin → 2-Bromoacetophenone
2. Bromoacetophenone + Hexamethylenetetramine → 2-Aminoacetophenone hydrochloride
3. 2-Aminoacetophenone hydrochloride + Ac2O → N-(2-Oxo-2-phenylethyl)acetamide
4. (2-Oxo-2-phenylethyl)acetamide + Glyoxylic acid 50% solution → Threo-2-hydroxy-3-acetylamino-4-oxo-4-phenylbutanoic acid
If you need Glyoxylic acid 50%, Threo-2-hydroxy-3-acetylamino-4-oxo-4-phenylbutanoic acid, Ubenimex, welcome to contact us.
